superporous ipn hydrogels having enhanced mechanical

superporous ipn hydrogels having enhanced mechanical

superporous ipn hydrogels having enhanced mechanical

Superporous IPN hydrogels having enhanced mechanical ...Gastric retention devices based on superporous IPN hydrogels (SPIHs) with the improved mechanical properties are expected to withstand compression pressure and mechanical frictions in the stomach better than the control SPHs. Keywords: superporous hydrogels, interpenetrating polymer networks, polyacrylonitrile, gastric retention devices, elasticity.

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(PDF) Superporous polyacrylate/chitosan IPN hydrogels

13. Qiu Y, Park K. Superporous IPN hydrogels having enhanced. mechanical properties. AAPS Pharm. Sci Tech. 2003;4(4): superporous ipn hydrogels having enhanced mechanical pore size, and the hydrogel's physical and mechanical (PDF) Interpenetrating network superporous hydrogels The effect of the strengthener, poly (vinyl alcohol) (PVA), on the swelling and mechanical behavior of the superporous hydrogels was investigated. The introduction of a small amount of PVA superporous ipn hydrogels having enhanced mechanical

Superporous IPN hydrogels having enhanced

Superporous IPN hydrogels having enhanced mechanical properties . By Yong Qiu and Kinam Park. Abstract. The objective of this study was to improve the mechanical properties of superporous hydrogels (SPHs), which were used to develop gastric retention devices for long-term oral drug delivery. The main approach used in this study was to form an superporous ipn hydrogels having enhanced mechanicalChitosan superporous hydrogel composite-based floating superporous ipn hydrogels having enhanced mechanicalSuperporous Hydrogel Composites (SPHCs), as the second generation of SPHs, possess improved mechanical properties over SPHs, with composite agents such as, Hydrogels having enhanced elasticity and mechanical superporous ipn hydrogels having enhanced mechanicalHydrogels having improved elasticity and mechanical strength properties are obtained by subjecting a hydrogel formulation containing a strengthening agent to chemical or physical crosslinking conditions subsequent to initial gel formation. Superporous hydrogels having improved elasticity and mechanical strength properties are similarly obtained whenever the hydrogel formulation is provided with a

Superporous hydrogels containing poly(acrylic acid-co superporous ipn hydrogels having enhanced mechanical

Feb 01, 2007 · Superporous hydrogels containing poly superporous ipn hydrogels having enhanced mechanical (AA-co-AM)/PEI) semi-IPNs which possess enhanced mechanical strength due to the high molecular entanglement associated with charge attraction between superporous ipn hydrogels having enhanced mechanical C.C. ChuSynthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels. Biomaterials, 25 (2004), pp. 3793-3805.Superporous polyacrylate/chitosan IPN hydrogels for superporous ipn hydrogels having enhanced mechanicalIn addition, ionically crosslinked chitosan (CH) superporous hydrogels were synthesized to form interpenetrating superporous hydrogels, i.e. poly(AAm)-CH and poly(AAm-co-AA)-CH SPH-IPNs. The hydrogels have a structure of interconnected pores with pore sizes of approximately 100150 m.Superporous polyacrylate/chitosan IPN hydrogels for superporous ipn hydrogels having enhanced mechanicalIn addition, ionically crosslinked chitosan (CH) superporous hydrogels were synthesized to form interpenetrating superporous hydrogels, i.e. poly(AAm)-CH and poly(AAm-co-AA)-CH SPH-IPNs. The hydrogels have a structure of interconnected pores with pore sizes of approximately 100150 m.

A Conceptual Overview on Superporous Hydrogels

Mechanical properties including compression strength and elasticity of super-porous IPN hydrogels (SPIHs) improve up to 50 times as compared with superporous hydrogels. Super-porous IPN hydrogels were prepared by interpenetrating polymer network by incorporating a second polymer network inside a superporous hydrogel structure.Advanced Hydrogel Structures | SpringerLinkY. Qiu, K. Park, Superporous IPN hydrogels having enhanced mechanical properties. AAPS PharmSciTech. 4 (4), 406412 (2003) PubMedCentral CrossRef PubMed Google ScholarAdvanced Hydrogel Structures | SpringerLinkY. Qiu, K. Park, Superporous IPN hydrogels having enhanced mechanical properties. AAPS PharmSciTech. 4 (4), 406412 (2003) PubMedCentral CrossRef PubMed Google Scholar

Biocompatible polypeptide-based interpenetrating

Herein, we present the synthesis of novel synthetic polypeptide-based interpenetrating network (IPN) hydrogels with enhanced mechanical properties. The polypeptide single network is obtained from alkyne functional polypeptides crosslinked with di, tri and tetra azide functional PEG by copper-catalysed alkyneazide cycloaddition (CuAAC).Chitosan superporous hydrogel composite-based floating superporous ipn hydrogels having enhanced mechanicalSuperporous Hydrogel Composites (SPHCs), as the second generation of SPHs, possess improved mechanical properties over SPHs, with composite agents such as, Chitosan,[32,33] Ac-Di-SolComparison of Various Generations of Superporous Further superporous hydrogel composites (SPHCs) (as discussed by Park et al. [710]) or by the formation of interpenetrating (as discussed by Qiu and Park ) or hybrid hydrogel network (as discussed by Omidian et al. ) have been developed with enhanced mechanical strength. Interpenetrating polymer networks (IPN) are a mixture of two or more superporous ipn hydrogels having enhanced mechanical

Comparison of Various Generations of Superporous

Further superporous hydrogel composites (SPHCs) (as discussed by Park et al. [710]) or by the formation of interpenetrating (as discussed by Qiu and Park ) or hybrid hydrogel network (as discussed by Omidian et al. ) have been developed with enhanced mechanical strength. Interpenetrating polymer networks (IPN) are a mixture of two or more cross-linked networks that are dispersed or mixed at a Dual crosslinked carboxymethyl cellulose/polyacrylamide superporous ipn hydrogels having enhanced mechanicalMar 15, 2020 · The synthesized CMC/PAM IPN hydrogels exhibited highly enhanced mechanical strength with high density internal structure due to the double crosslinking of CMC and PAM. The tensile length and compressive strengths of CMC/PAM-1 IPN hydrogels were up to 2.6 and 4.5 times higher than that of the CMC gel, respectively.Effect of crosslinker concentration on characteristics of superporous ipn hydrogels having enhanced mechanicalA superporous hydrogel should be able to withstand the pressure expected in the stomach during repeated gastric contractions, especially the housekeeper waves. Formulation variables, such as the amount of crosslinker, type of monomer, amount of blowing agent as well as process variables all affect the mechanical properties of SPHs.

Enhancing Biopolymer Hydrogel Functionality through superporous ipn hydrogels having enhanced mechanical

Sep 16, 2020 · By virtue of secondary networks, IPN hydrogels can readily achieve tough mechanical properties, smart responsiveness, and the ability to closely recapitulate complex cellmaterial interactions for applications in drug delivery, tissue engineering, in GASTRORETENTIVE SUPERPOROUS HYDROGEL TABLETS Mechanical Properties: The tensile strength (T) of superporous hydrogel formulations, which is a measure of the stress necessary to cause diametral fracture of the compact, was determined from the mean data obtained from the hardness test carried out on the SPHs (n = 3) using the Mosanto hardness tester. The T values were computed from equation below,PolySciTech® - AQUAGELTo maintain the mechanical strength of fully swollen hydrogels, the swelling ratio can be lowered to less than 100 by increasing the crosslinking density. The enhanced mechanical property can also be obtained by making superporous hydrogel composites and/or elastic superporous hydrogels.

Role of active nanoliposomes in the surface and bulk superporous ipn hydrogels having enhanced mechanical

Mar 01, 2020 · Semi-IPN hydrogel preparation, by alginate gelation with CaCl 2, is the first step of the IPN gelation procedure, which is then followed by GelMA cross-linking via UV exposure. Considering that the cross-linked alginate provides the majority of the mechanical stability of the IPN hydrogels, the incorporation of nanoliposomes interferes with the superporous ipn hydrogels having enhanced mechanicalStructure and properties of cellulose/poly(N superporous ipn hydrogels having enhanced mechanicalAug 23, 2011 · Interpenetrating polymer network (IPN) strategy was developed to fabricate novel hydrogels composed of cellulose and poly(Nisopropylacrylamide) (PNIPAAm) with high mechanical strength and adjustable thermosensitivity. Cellulose hydrogels were prepared by chemically crosslinking cellulose in NaOH/urea aqueous solution, which were employed as the first network.Superporous IPN Hydrogels Having Enhanced porous IPN hydrogels (SPIHs) with the improved me-chanical properties are expected to withstand compres-sion pressure and mechanical frictions in the stomach better than the control SPHs. KEYWORDS: superporous hydrogels, interpenetrating polymer networks, polyacrylonitrile, gastric retention devices, elasticity

Superporous IPN hydrogels having enhanced mechanical superporous ipn hydrogels having enhanced mechanical

IPN hydrogels endowed with enhanced mechanical properties have been prepared by a sequential technique incorporating a second polymer network inside a super-porous hydrogel. Mechanical properties superporous ipn hydrogels having enhanced mechanicalSuperporous IPN hydrogels having enhanced mechanical superporous ipn hydrogels having enhanced mechanicalDec 01, 2003 · Superporous IPN hydrogels having enhanced mechanical properties Abstract. The objective of this study was to improve the mechanical properties of superporous hydrogels (SPHs), which superporous ipn hydrogels having enhanced mechanical References. Chen J, Park H, Park K. Superporous hydrogels: fast responsive hydrogel systems. Proc ACS Div Polym Mat superporous ipn hydrogels having enhanced mechanicalSuperporous IPN hydrogels having enhanced mechanical superporous ipn hydrogels having enhanced mechanicalGastric retention devices based on superporous IPN hydrogels (SPIHs) with the improved mechanical properties are expected to withstand compression pressure and mechanical frictions in the stomach better than the control SPHs. Keywords: superporous hydrogels, interpenetrating polymer networks, polyacrylonitrile, gastric retention devices, elasticity.

Superporous IPN hydrogels having enhanced mechanical superporous ipn hydrogels having enhanced mechanical

Oct 13, 2003 · Gastric retention devices based on superporous IPN hydrogels (SPIHs) with the improved mechanical properties are expected to withstand compression pressure and mechanical frictions in the stomach better than the control SPHs.Swelling and Mechanical Properties of Modified HEMA Hydrogels Having Enhanced Elasticity and Mechanical Strength Properties, US Patent 6,960, 617. superporous ipn hydrogels having enhanced mechanical Swelling and Mechanical Properties of Glycol Chitosan/Poly(vinyl alcohol) IPN-type Superporous Hydrogels, Journal of Biomedical Materials Research; Part A, 78A(4): 662-667.Swelling and Mechanical Properties of Modified HEMA Abstract. Superporous hydrogels (SPHs), based on poly (2-hydroxyethyl methacrylate) (PHEMA), were prepared by adding minute amounts of an ion-complexable hydrophilic acrylic acid. PHEMA SPHs are generally strong, but their swelling is minimal. To improve the swelling, different poly (HEMA-co-acrylic acid) hydrogels were polymerized and crosslinked, then physically treated with divalent calcium and

Swelling and mechanical properties of glycol

May 31, 2006 · The effect of the molecular weight of the strengthener, poly (vinyl alcohol) (PVA), on the swelling and mechanical behavior of the superporous hydrogels was investigated. The introduction of a small amount of high molecular weight PVA significantly enhanced the mechanical strength but slightly reduced the swelling capacity.Synthesis characterization and in vitro drug release from superporous ipn hydrogels having enhanced mechanicalTreatment with CaCl 2 resulted in the formation of hydrogels with desired mechanical strength by significantly improving the structural integrity of the hydrogel and decreased stress relaxation, which enhanced its ability to withstand pressure of gastric fluids. The increase in calcium chloride concentration (up to 10%) has no significant impact on mechanical strength rather it affected equilibrium swelling Synthesis of superporous hydrogels: Hydrogels with fast superporous ipn hydrogels having enhanced mechanicalYong Qiu and Kinam Park, Superporous IPN hydrogels having enhanced mechanical properties, AAPS PharmSciTech, 10.1208/pt040451, 4, 4, (406-412), (2003). Crossref

[PDF] Drug delivery applications for superporous

Introduction: Considerable advances have been made to hydrogels with the development of faster swelling superporous hydrogels (SPHs). These new-generation hydrogels have large numbers of interconnected pores, giving them the capacity to absorb large amounts of water at an accelerated rate. This gives SPHs the ability to be used in a variety of novel drug delivery applications, such as gastric superporous ipn hydrogels having enhanced mechanical[PDF] Drug delivery applications for superporous Introduction: Considerable advances have been made to hydrogels with the development of faster swelling superporous hydrogels (SPHs). These new-generation hydrogels have large numbers of interconnected pores, giving them the capacity to absorb large amounts of water at an accelerated rate. This gives SPHs the ability to be used in a variety of novel drug delivery applications, such as gastric superporous ipn hydrogels having enhanced mechanical

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